关键词: 紫杉醇产生菌, 培养基优化, 菌种改良, taxol-producing microorganisms, optimization of the culture medium, improvement of strain, 紫杉醇产生菌, 培养基优化, 菌种改良

Abstract: For its environmentally acceptable，relatively simple and inexpensive features，microor-ganisms fermentation has been investigated as a potential alternatives to solve the crisis of raw material. No commercial fermentation strain has been used so far，because of the low production. The aim of this study is to review and analysis the present status of research on paclitaxel-producing by microorganisms，screening of paclitaxel-producing microorganisms，optimization of the culture medium，genes of the paclitaxel biosynthesis and improvement of the taxol-producing microorganisms.

Key words: taxol-producing microorganisms, optimization of the culture medium, improvement of strain